| Date | Location | Result | |
| 02/22/22 | Washington, PA | Wash. & Jeff. 77, Waynesburg 45 | Box score |
| 02/21/22 | Waynesburg, PA | Waynesburg 63, Thiel 53 | Box score |
| 02/19/22 | Waynesburg, PA | Geneva 78, Waynesburg 73 | Box score |
| 02/16/22 | Waynesburg, PA | Bethany (WV) 83, Waynesburg 48 | Box score |
| 02/14/22 | Waynesburg, PA | Waynesburg 79, Thiel 58 | Box score |
| 02/12/22 | Waynesburg, PA | Westminster (PA) 58, Waynesburg 57 | Box score |
| 02/09/22 | Washington, PA | Wash. & Jeff. 75, Waynesburg 49 | Box score |
| 02/05/22 | Waynesburg, PA | Chatham 63, Waynesburg 52 | Box score |
| 02/02/22 | Greenville, PA | Waynesburg 83, Thiel 66 | Box score |
| 01/29/22 | Steubenville, OH | Waynesburg 68, Franciscan 48 | Box score |
| 01/26/22 | Waynesburg, PA | Waynesburg 60, Saint Vincent 59 | Box score |
| 01/24/22 | AFC in Pittsburgh, Pa. | Chatham 66, Waynesburg 54 | Box score |
| 01/22/22 | Waynesburg, PA | Grove City 60, Waynesburg 55 | Box score |
| 01/20/22 | Bethany, WV | Bethany (WV) 72, Waynesburg 51 | Box score |
| 01/15/22 | Beaver Falls, PA | Geneva 79, Waynesburg 78 | Box score |
| 01/12/22 | Waynesburg, PA | Wash. & Jeff. 75, Waynesburg 64 | Box score |
| 01/08/22 | New Wilmington, PA | Westminster (PA) 65, Waynesburg 50 | Box score |
| 12/17/21 | Waynesburg, PA | Ohio Wesleyan 69, Waynesburg 39 | Box score |
| 12/04/21 | Waynesburg, PA | Waynesburg 83, Franciscan 55 | Box score |
| 12-1-21 | Grove City, Pa. - Grove City Coll. Arena | Grove City 63, Waynesburg 55 | Box score |
| 11/27/21 | Latrobe, PA | Saint Vincent 72, Waynesburg 67 | Box score |
| 11/23/21 | Westerville, OH | Otterbein 90, Waynesburg 62 | Box score |
| 11/20/21 | Erie, PA | Penn St.-Behrend 80, Waynesburg 52 | Box score |
| 11/19/21 | The Nielsen Center | Houghton 63, Waynesburg 56 | Box score |
| 11/16/21 | Waynesburg, PA | CWRU 91, Waynesburg 67 | Box score |
| 11/05/21 | Hiram, OH | Hiram 89, Waynesburg 83 (OT) | Box score |