| Date | Location | Result | |
| 3/2/2022 | Memorial Gymnasium | Juniata 55, Waynesburg 45 | Box score |
| 02/24/22 | Washington, PA | Wash. & Jeff. 66, Waynesburg 61 | Box score |
| 02/22/22 | Beaver Falls, PA | Waynesburg 60, Geneva 59 | Box score |
| 02/19/22 | Waynesburg, PA | Geneva 80, Waynesburg 67 | Box score |
| 02/16/22 | Waynesburg, PA | Waynesburg 81, Bethany (WV) 44 | Box score |
| 02/14/22 | Waynesburg, PA | Thiel 55, Waynesburg 50 (OT) | Box score |
| 02/12/22 | Waynesburg, PA | Westminster (PA) 57, Waynesburg 54 | Box score |
| 02/09/22 | Washington, PA | Wash. & Jeff. 68, Waynesburg 63 | Box score |
| 02/05/22 | Waynesburg, PA | Chatham 61, Waynesburg 49 | Box score |
| 02/02/22 | Greenville, PA | Waynesburg 68, Thiel 56 | Box score |
| 01/29/22 | Steubenville, OH | Franciscan 84, Waynesburg 74 | Box score |
| 01/26/22 | Waynesburg, PA | Waynesburg 60, Saint Vincent 43 | Box score |
| 01/24/22 | AFC in Pittsburgh, Pa. | Chatham 80, Waynesburg 63 | Box score |
| 01/22/22 | Waynesburg, PA | Waynesburg 76, Grove City 62 | Box score |
| 01/20/22 | Bethany, WV | Waynesburg 78, Bethany (WV) 56 | Box score |
| 01/18/22 | New Wilmington, PA | Westminster (PA) 71, Waynesburg 51 | Box score |
| 01/15/22 | Beaver Falls, PA | Waynesburg 78, Geneva 73 | Box score |
| 01/12/22 | Waynesburg, PA | Wash. & Jeff. 61, Waynesburg 52 | Box score |
| 12/30/21 | Waynesburg, PA | Waynesburg 83, Stevenson 69 | Box score |
| 12/20/21 | Gambier, OH | Kenyon 68, Waynesburg 49 | Box score |
| 12/15/21 | Waynesburg, PA | Waynesburg 81, Muskingum 65 | Box score |
| 12/04/21 | Waynesburg, PA | Waynesburg 75, Franciscan 67 | Box score |
| 12-1-21 | Grove City, Pa. - Grove City Coll. Arena | Waynesburg 62, Grove City 52 | Box score |
| 11/27/21 | Latrobe, Pa. | Waynesburg 74, Saint Vincent 48 | Box score |
| 11/23/21 | Westerville, OH | Otterbein 78, Waynesburg 57 | Box score |
| 11/20/21 | Hiram, OH | Waynesburg 73, Hiram 67 (OT) | Box score |
| 11/13/21 | Erie, PA | Waynesburg 60, Penn St.-Behrend 57 (OT) | Box score |
| 11/09/21 | Waynesburg, PA | Oberlin 45, Waynesburg 42 | Box score |