| Date | Location | Result | |
| Nov 13, 2021 | Washington, Pa. | Wash. & Jeff. 55, Waynesburg 0 | Box score |
| Nov 06, 2021 | Waynesburg, Pa. | Waynesburg 31, Bethany 7 | Box score |
| 10/30/21 | Beaver Falls, Pa. | Geneva 49, Waynesburg 3 | Box score |
| Oct 23, 2021 | Waynesburg, Pa. | Saint Vincent 38, Waynesburg 7 | Box score |
| Oct 16, 2021 | New Wilmington, Pa. | Westminster 66, Waynesburg 14 | Box score |
| Oct 02, 2021 | Waynesburg, Pa. | Grove City 38, Waynesburg 0 | Box score |
| Sep 25, 2021 | Pittsburgh, Pa. | Carnegie Mellon 39, Waynesburg 3 | Box score |
| Sep 18, 2021 | Waynesburg, PA | Waynesburg 52, Thiel 14 | Box score |
| Sep 11, 2021 | Waynesburg, Pa. | Case Western Reserve 66, Waynesburg 33 | Box score |
| Sep 04, 2021 | Zanesville HS | Muskingum 49, Waynesburg 6 | Box score |